While it is important to try to cure the infection itself, management of the consequences of that infection (particularly the lymphoedema, elephantiasis and hydroceles) is what is the greatest concern to the patient. Interestingly, with respect to hydroceles it has now been shown repeatedly that treatment of infection in communities with either intermittent (monthly, 6-monthly, yearly) drug administration or the steady use of DEC-fortified table/cooking salt, can lead to clinical improvement with decreases in both hydrocele size and prevalence. Similarly, it is not uncommon to find early lymphoedema regressing completely after treatment of an affected patient with DEC.

In more chronic states, larger hydroceles that do not regress spontaneously or after treatment must be subjected to surgical procedures in order to drain the fluid and render the tunica vaginalis incapable of trapping and retaining it again.